发明名称 |
LIPID MEMBRANE STRUCTURE WITH NUCLEAR TRANSFERABILITY |
摘要 |
A lipid membrane structure for delivering a substance into a nucleus of a cell, wherein lipid membrane is modified with (a) a polypeptide comprising the amino acid sequence of SEQ ID NO: 1, and/or (b) a polypeptide consisting of an amino acid sequence comprising the amino acid sequence of SEQ ID NO: 1, but including deletion and/or substitution and/or insertion of one or several amino acid residues, and having an activity of promoting migration of the lipid membrane structure into a nucleus of a cell, which can efficiently deliver a nucleic acid into a nucleus of an immunocyte such as dendritic cell. |
申请公布号 |
EP2572706(A1) |
申请公布日期 |
2013.03.27 |
申请号 |
EP20110772046 |
申请日期 |
2011.04.20 |
申请人 |
NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY;KYOTO UNIVERSITY |
发明人 |
HARASHIMA, HIDEYOSHI;AKITA, HIDETAKA;SHARIF, MOHAMMAD SHAHEEN;NAKAMURA, TAKASHI;ISHII, SOICHIRO;FUTAKI, SHIROH |
分类号 |
A61K9/127;A61K31/711;A61K38/00;A61K47/10;A61K47/34;A61K48/00;A61P35/00;C07K14/11;C12N15/88 |
主分类号 |
A61K9/127 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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