| 发明名称 |
Isoindoline compounds for the treatment of spinal muscular atrophy and other uses |
| 摘要 |
<p>Disclosed is a compound of Formula I
in which W and R 1 -R 6 are defined herein. Also disclosed is a method of treating spinal muscular atrophy, as well as methods of using such compounds to increase SMN expression, increase EAAT2 expression, or increase the expression of a nucleic acid that encodes a translational stop codon introduced directly or indirectly by mutation or frameshift.</p> |
| 申请公布号 |
EP2573080(A1) |
申请公布日期 |
2013.03.27 |
| 申请号 |
EP20120198010 |
申请日期 |
2008.09.26 |
| 申请人 |
THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES;ALBANY MOLECULAR RESEARCH, INC. |
发明人 |
HEEMSKERK, JILL E.;MCCALL, JOHN M.;BARNES, KEITH D. |
| 分类号 |
C07D401/04;A61K31/4035;A61P21/00;C07D403/04;C07D405/04;C07D409/04 |
主分类号 |
C07D401/04 |
| 代理机构 |
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代理人 |
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| 主权项 |
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| 地址 |
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