| 摘要 |
<p num="1"><br/><br/>Dihydropyridine calcium antagonist compounds, preparation methods and medical <br/>uses thereof are disclosed. <br/>Particularly, preparation methods of compounds of general formula (I) and (II) <br/>and pharmaceutically acceptable salts thereof, <br/>and their uses in the treatment of cardiovascular diseases are disclosed, <br/>wherein R1 represents substituted or unsubstituted <br/>heterocyclic, aromatic ring or aralkyl group, the substituents may be C1-<br/>C4alkyl, C1-C4alkoxyl, halogen, cyano, trifluoromethyl, <br/>trifluoromethoxyl, methylthio, nitro, amino or hydroxyl; R2 represents C1-<br/>C8alkyl; R3 and R4 may be same or different, <br/>and each independently represents hydrogen, halogen, cyano, trifluoromethyl, <br/>trifluoromethoxyl, methylthio, nitro, amino or <br/>C1-C4alkyl, C1-C4alkoxyl, C1-C4alkenyl, C1-C4alkynyl; R5 and R6 are same or <br/>different, and each represents C1-C4alkyl; X <br/>represents O, S or a single bond; m=0-6, n=1-6, and m and n may be same or <br/>different.<br/><br/><br/><br/>
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