发明名称 |
Antibodies to the NOTCH1 receptor |
摘要 |
The present invention relates to compositions and methods for characterizing, diagnosing, and treating cancer. In particular the invention provides the means and methods for the diagnosis, characterization, prognosis and treatment of cancer and specifically targeting cancer stem cells. The present invention provides an antibody that specifically binds to a non-ligand binding region of the extracellular domain of a human NOTCH receptor and inhibits growth of tumor cells. The present invention further provides a method of treating cancer, the method comprising administering a therapeutically effective amount of an antibody that specifically binds to a non-ligand binding region of the extracellular domain of a human NOTCH receptor protein and inhibits growth of tumor cells.
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申请公布号 |
US8404237(B2) |
申请公布日期 |
2013.03.26 |
申请号 |
US201213472301 |
申请日期 |
2012.05.15 |
申请人 |
LEWICKI JOHN A.;GURNEY AUSTIN;HOEY TIMOTHY;YEN WAN-CHING;SATYAL SANJEEV;ONCOMED PHARAMACEUTICALS, INC. |
发明人 |
LEWICKI JOHN A.;GURNEY AUSTIN;HOEY TIMOTHY;YEN WAN-CHING;SATYAL SANJEEV |
分类号 |
A61K39/395;C07K14/705;C07K16/28;C12N5/07 |
主分类号 |
A61K39/395 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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