发明名称 |
Method of identifying membrane Ig specific antibodies and use thereof for targeting immunoglobulin-producing precursor cells |
摘要 |
The present invention relates to the discovery of antibodies that bind to novel epitopes present on membrane-anchored immunoglobulins and which bind to these novel epitopes on the surface of B cells and plasma cells. In addition, the antibodies of the present invention can mediate ADCC and can be useful to deplete those B cells and plasma cells expressing the novel epitopes of the invention. The antibodies of the present invention can be useful for the treatment of B cell-mediated diseases and diseases caused by monoclonal expansion of B cells. Accordingly the present invention also provides compositions and methods for the prevention, management, treatment or amelioration of B cell-mediated diseases and diseases caused by monoclonal expansion of B cells.
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申请公布号 |
US8404236(B2) |
申请公布日期 |
2013.03.26 |
申请号 |
US201213372170 |
申请日期 |
2012.02.13 |
申请人 |
WU HERREN;KIENER PETER;CHOWDHURY PARTHA S.;YOUNG JAMES F.;MEDIMMUNE, LLC |
发明人 |
WU HERREN;KIENER PETER;CHOWDHURY PARTHA S.;YOUNG JAMES F. |
分类号 |
A61K39/00 |
主分类号 |
A61K39/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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