发明名称 |
Unit dose formulations and methods of treating thrombosis with an oral factor Xa inhibitor |
摘要 |
Unit doses of factor Xa inhibitor compounds and methods of using these compounds for inhibiting blood coagulation in a human patient are taught herein. The unit dose of the factor Xa inhibitor compounds disclosed herein required to inhibit coagulation in a primate is lower than the unit dose required to obtain similar levels of coagulation inhibition in other animal models, such as rodents. Also taught are in vitro assays useful in predicting in vivo antithrombotic activity in humans. |
申请公布号 |
US8404724(B2) |
申请公布日期 |
2013.03.26 |
申请号 |
US20070999957 |
申请日期 |
2007.12.07 |
申请人 |
SINHA UMA;HOLLENBACH STANLEY J.;ABE KEITH;MILLENNIUM PHARMACEUTICALS, INC. |
发明人 |
SINHA UMA;HOLLENBACH STANLEY J.;ABE KEITH |
分类号 |
A61K31/4402 |
主分类号 |
A61K31/4402 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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