发明名称 |
Method for generating aptamers with improved off-rates |
摘要 |
The present disclosure is directed to the field of nucleic acid chemistry, specifically to 5-position modified uridines, as well as, oligonucleotides comprising said 5-position modified uridines. The present disclosure describes methods for producing aptamers comprising said 5-position modified uridines that are capable of binding to target molecules. |
申请公布号 |
US8404830(B2) |
申请公布日期 |
2013.03.26 |
申请号 |
US20100969239 |
申请日期 |
2010.12.15 |
申请人 |
ZICHI DOMINIC;WILCOX SHERI K.;BOCK CHRIS;SCHNEIDER DANIEL J.;EATON BRUCE;GOLD LARRY;SOMALOGIC, INC. |
发明人 |
ZICHI DOMINIC;WILCOX SHERI K.;BOCK CHRIS;SCHNEIDER DANIEL J.;EATON BRUCE;GOLD LARRY |
分类号 |
C07H19/00;C07H21/04 |
主分类号 |
C07H19/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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