Normal;heading 1;heading 2;heading 3;OXADIAZOLE DERIVATIVES ACTIVE ON SPHINGOSINE-1-PHOSPHATE (S1P)

摘要

The present application discloses oxadiazole based compounds of Formula (I) active on sphingosine-1-phosphate (SIP) in particular useful to treat lupus erythematosus. A is phenyl or a 5 or 6-membered heteroaryl ring; Ris up to two substituents independently selected from halogen, Calkoxy, Cfluoroalkyl, cyano, optionally substituted phenyl, Cfluoroalkoxy, Calkyl and Ccyctoalkyl; Ris hydrogen, halogen or Calkyl; B is a 7 membered saturated ring selected from the formulae (a) (b) (c), Ris hydrogen or (CH)MCOH; Ris hydrogen or Calkyl optionally interrupted by oxygen.