Polycyclic carbamoylpyridone derivative having inhibitory activity on HIV integrase

摘要

The invention provides a compound with antivirus function, especially HIV integrase inhibition activity, and medicine containing the compound, especially HIV inhibiting medicine. The compound is expressed by the general formula (I) in which, R1 expresses hydrogen or low grade alkyl radical; X expresses low grade alkylidene radical; R2 expresses substitutable aryl radical; R3 expresses hydrogen, halogen, hydroxyl radical; R4 expresses hydrogen and substitutable low grade alkyl radical; broken line expresses existing or dis-existing; one of B1 and B2 is CR20R21, the other one is NR22, here the broken line does not exist; or B1 and B2 separated from each other are C, CR23 or N, B1 and B2 can be partly formed into substitutable heterocycle; R20, R21, R22 and R23 are independent from each other, express hydrogen, substitutable low grade alkyl radical, substitutable cycloalkyl radical and substitutable cycloalkyl low grade alkyl radical.