GENETICALLY MODIFIED VESICULAR STOMATITIS VIRUS (VSV), VECTOR COMPRISING IT AND IMMUNOGENIC COMPOSIITON COMPRISING SAID VECTOR

摘要

The present invention broadly relates to the synergistic attenuation of vesicular stomatitis virus (VSV), More particularly, the invention relates to the identification of combined mutation classes which synergistically attenuate the pathogenicity of VSV vectors in mammals and immunogenic compositions thereof.