发明名称 |
RECOMBINANT CO-EXPRESSION OF VITAMIN K EPOXIDE REDUCTASE SUBUNIT 1 TO IMPROVE VITAMIN K DEPENDENT PROTEIN EXPRESSION |
摘要 |
The present invention relates to a host organism containing recombinant nucleic acids coding for the vitamin K reductase complex subunit 1 (VKORC1) and recombinant nucleic acids coding for a vitamin K dependent (VKD) protein, wherein both the recombinant VKORC1 and the recombinant VKD protein are expressed in said host organism. Further, the present invention relates to a cell culture system comprising cells which contain said recombinant nucleic acids and to methods for improving the productivity of recombinant VKD protein expression in a host organism being cultured in suitable systems. |
申请公布号 |
HK1113498(A1) |
申请公布日期 |
2013.03.22 |
申请号 |
HK20080103591 |
申请日期 |
2008.04.01 |
申请人 |
BAXTER INTERNATIONAL INC.;BAXTER HEALTHCARE SA |
发明人 |
SCHEIFLINGER, FRIEDRICH;BOEHM, ERNST |
分类号 |
C12N |
主分类号 |
C12N |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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