| 摘要 |
PURPOSE: An siRNA hydrogel for gene targeting with a three-dimensional network structure is provided to stably and efficiently deliver a gene into a cell and to ensure high biocompatibility. CONSTITUTION: An siRNA hydrogel for gene targeting with a three-dimensional network structure has structural formula 1 or 2. In structural formula 1 or 2, X1, X2, and X3 are a sense siRNA monomer in which a first functional group is introduced; Y1, Y2, and Y3 are an antisense siRNA monomer in which a second functional group is introduced; A exists or does not exist, A is a crosslinker or a polymer if A exist; and n is an integer. The sense siRNA monomer or the antisense siRNA monomer has 13-60 nucleic acids. |
