发明名称 |
NEUREGULIN-1-BASED PROGNOSIS AND THERAPEUTIC STRATIFICATION OF COLORECTAL CANCER |
摘要 |
The present invention relates to the prognosis, therapeutic stratification and treatment of colorectal cancer. More in particular, the present invention discloses that significantly increased levels of transmembrane type 1 neuregulin-1 in tumor-associated mesenchymal cells present in a sample of a patient indicate that the patient has a worse prognosis when compared to patients having low levels of transmembrane type 1 neuregulin-1 in tumor-associated mesenchymal cells. Moreover, the present invention relates to the usage of transmembrane type 1 neuregulin-1 expression in tumor-associated mesenchymal cells to predict resistance to HER1 inhibitors during colorectal cancer therapy and/or to predict whether a patient would benefit from a therapy based on the prevention of neuregulin-1 and/or HER3 activity. |
申请公布号 |
WO2013037789(A1) |
申请公布日期 |
2013.03.21 |
申请号 |
WO2012EP67758 |
申请日期 |
2012.09.12 |
申请人 |
UNIVERSITEIT GENT;DE WEVER, OLIVIER;DE BOECK, ASTRID |
发明人 |
DE WEVER, OLIVIER;DE BOECK, ASTRID |
分类号 |
G01N33/574 |
主分类号 |
G01N33/574 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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