发明名称 |
ASSAYS AND METHODS USING BIOMARKERS |
摘要 |
Methods and assays examining expression of one or more biomarkers in a mammalian tissue or cell sample are provided. According to the disclosed methods and assays, detection of the expression of GalNac-T related molecules, such as GalNac-T14 or GalNac-T3, is predictive or indicative that the tissue or cell sample will be sensitive to apoptosis-inducing agents such as Apo2L/TRAIL and anti-DR5 agonist antibodies. Kits and articles of manufacture are also provided. |
申请公布号 |
US2013072429(A1) |
申请公布日期 |
2013.03.21 |
申请号 |
US201213444500 |
申请日期 |
2012.04.11 |
申请人 |
ASHKENAZI AVI J.;WAGNER KLAUS W.;GENENTECH, INC. |
发明人 |
ASHKENAZI AVI J.;WAGNER KLAUS W. |
分类号 |
G01N33/574;A61K38/17;A61K38/19;C12Q1/37;C12Q1/68 |
主分类号 |
G01N33/574 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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