TASTE MASKED PHARMACEUTICAL COMPOSITIONS OF CEFUROXIME AXETIL

摘要

The invention relates to a process for preparation of taste masked and nongelling pharmaceutical compositions of Cefuroxime or its pharmaceutically acceptable salts such as Cefuroxime axetil with lipid or mixture of lipids to mask the bitter taste of Cefuroxime axetil using hot melt extrusion technique. The process comprises dispersing of Cefuroxime axetil in melted lipid or the mixture of lipids, solidification of the molten lipid or mixture of lipids on the particulate Cefuroxime or its pharmaceutically acceptable salts, and recovering said lipid or mixture of lipids coated Cefuroxime particles. The invention also relates to taste masked non gelling pharmaceutical composition of Cefuroxime or its pharmaceutically acceptable salt prepared by hot melt extrusion technique.