SOLID DISPERSION OF POORLY SOLUBLE COMPOUNDS COMPRISING CROSPOVIDONE AND AT LEAST ONE WATER-SOLUBLE POLYMER
摘要
A stable ternary solid dispersion composition with enhanced physical stability and/or bioavailability comprising: (a) about 1% wt. to about 50% wt. of one or more poorly soluble active pharmaceutical ingredient (API) which belongs to Biopharmaceutics Classification System (BCS) class II and/or IV; (b) about 11% wt. to about 50% wt. of at least one water- soluble polymer; and (c) about 20% wt. to about 99% wt. of crosslinked polyvinylpyrrolidone (crospovidone, a water-insoluble polymer). The solid dispersion is capable of inhibiting crystallization of API in solid state and/or aqueous gastrointestinal tract (GIT) medium. Also disclosed is a method of preparation of such solid dispersion composition by fusion or solvent or fusion- solvent method.
申请公布号
WO2013040187(A1)
申请公布日期
2013.03.21
申请号
WO2012US55129
申请日期
2012.09.13
申请人
ISP INVESTMENTS INC.;BI, YUNXIA;RAHMAN, MOHAMMED, ABDUL;LESTER, JAMES, DAVID
发明人
BI, YUNXIA;RAHMAN, MOHAMMED, ABDUL;LESTER, JAMES, DAVID