发明名称 |
BACTERIAL STRAINS ISOLATED FROM PIGS |
摘要 |
A first aspect of the invention relates to a porcine lactic acid bacterial strain, wherein said bacterial strain is characterised by one or more of the following characteristics: (i) the ability to exhibit antimicrobial activity against E. coli; (ii) the ability to exhibit antimicrobial activity against S. enteritidis; (iii) the ability to suppress inflammation in IPEC cells induced by 12-0- tetradecaboylphorbol-13-acetate (PMA); (iv) the ability to block the attachment or invasion of IPEC cells by S. enteritidis; (v) the ability to block the attachment or invasion of IPEC cells by E. coli; (vi) the absence of antibiotic resistance to one or more antibiotics selected from the following: ampicillin; cefotaxime; chloramphenicol; erythromycin; gentamicin; tetracycline; vancomycin; metronizadole; nalidixic acid; and kanamycin; and (vii) the ability to exhibit heat stability when subjected to three cycles of heating, each cycle comprising heating at a temperature of 70 °C for a period of 15 minutes. Further aspects of the invention relate to compositions comprising said bacterial strains, and therapeutic uses of said bacterial strains. |
申请公布号 |
WO2013008039(A3) |
申请公布日期 |
2013.03.21 |
申请号 |
WO2012GB51686 |
申请日期 |
2012.07.13 |
申请人 |
GT BIOLOGICS LTD;KELLY, DENISE |
发明人 |
KELLY, DENISE |
分类号 |
C12N1/00;A23L1/30;A61K35/74;C12R1/225;C12R1/23;C12R1/25 |
主分类号 |
C12N1/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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