发明名称 |
INHIBITORS OF NOX4 EXPRESSION AND/OR NOX4 FUNCTION AND THEIR USE IN THE PREVENTION AND TREATMENT OF NERVE INJURY AND/OR NEUROPATHIC PAIN |
摘要 |
The present invention relates to modulators, in particular inhibitors, of the expression and/or the function of NADPH Oxidase 4 (Nox4) for use in the prevention and/or treatment of nerve injury, in particular pain, more particularly neuropathic pain. Further disclosed is a method for the identification of Nox4 modulators, a pharmaceutical composition comprising a Nox4 inhibitor and a method for preventing and treating pain, in particular neuropathic pain, in a subject in need of such a treatment. Also, the invention relates to modulators, in particular inhibitors, of the expression and/or the function of NADPH Oxidase 4 (Nox4) for use in the prevention and/or treatment of nerve injury associated with dysmyelination and methods for preventing and treating dysmyelination and diseases associated with dysmyelination. |
申请公布号 |
WO2013037499(A1) |
申请公布日期 |
2013.03.21 |
申请号 |
WO2012EP03857 |
申请日期 |
2012.09.14 |
申请人 |
JOHANN WOLFGANG GOETHE-UNIVERSITAET;SCHMIDTKO, ACHIM;KALLENBORN-GERHARDT, WIEBKE;GEISSLINGER, GERD;BRANDES, RALF;SCHROEDER, KATRIN |
发明人 |
SCHMIDTKO, ACHIM;KALLENBORN-GERHARDT, WIEBKE;GEISSLINGER, GERD;BRANDES, RALF;SCHROEDER, KATRIN |
分类号 |
C12Q1/68;A61K31/7088;A61K31/713;A61P25/04;C12N15/113 |
主分类号 |
C12Q1/68 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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