发明名称 |
METHODS FOR MONITORING RESPONSIVENESS TO ANTI-SMAD7 THERAPY |
摘要 |
Methods for monitoring whether a subject will be sensitive or resistant to treatment with an anti-SMAD7 therapy are disclosed. The methods are based on the determining of the amount of CCR9+ FOXP3+ T cells, CCR9+ IFN-gamma+ T cells, CCR9+ IL17A+ T cells, FOXP3+ T cells, IFN-gamma+ T cells, and/or IL17A+ T cells in a sample from the subject. Measurement of T cell populations may be determined by flow cytometry, immunohistochemsistry, and/or ELISA. |
申请公布号 |
WO2013037970(A1) |
申请公布日期 |
2013.03.21 |
申请号 |
WO2012EP68146 |
申请日期 |
2012.09.14 |
申请人 |
NOGRA PHARMA LIMITED;MONTELEONE, GIOVANNI;VITI, FRANCESCA;BELLINVIA, SALVATORE |
发明人 |
MONTELEONE, GIOVANNI;VITI, FRANCESCA;BELLINVIA, SALVATORE |
分类号 |
G01N33/68;G01N33/50 |
主分类号 |
G01N33/68 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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