The present invention relates to the use of a DNA expression construct comprising a dumbbell- shaped circular strand of deoxyribonucleic acids and provides such a construct with a double- stranded stem and single-stranded loops located at both ends of the stem, wherein the stem comprises complementary deoxyribonucleic acids of the circular strand with a promotor sequence, a coding sequence and a termination signal to be administered by jet injection for the treatment of cancer.
申请公布号
AU2011298756(A1)
申请公布日期
2013.03.21
申请号
AU20110298756
申请日期
2011.09.08
申请人
MAX-DELBRUCK-CENTRUM FUR MOLEKULARE MEDIZIN (MDC)BERLIN-BUCH;MOLOGEN AG
发明人
WALTHER, WOLFGANG;SCHLAG, PETER M.;KOBELT, DENNIS;SCHMIDT, MANUEL