发明名称 |
QUINOLINE DERIVATIVES, IN PARTICULAR 5,6,7-SUBSTITUTED 1-(2-CHLOROQUINOLIN-3-YL)- 4-DIMETHYLAMINO-2-(NAPHTHALEN-1-YL)-1-PHENYLBUTAN-2-OLS, METHOD FOR PRODUCING SAME AND USE OF SAID COMPOUNDS |
摘要 |
The present invention relates to novel quinoline derivatives, such as substituted 1-(2-chloroquinolin-3-yl)-4-dimethylamino-2-(naphthalen-1-yl)-1- phenylbutan-2-ols, to a method for producing same, and also to the use thereof as antimycobacterial agents, in particular to 5,6,7-substituted 1-(2-chloroquinolin-3-yl)-4-dimethylamino-2-(naphthalen-1-yl)-1- phenylbutan-2-ols of general formula (I), where R1 is Н or methoxy, R2 is Н, methoxy or -O-(CH2)n-O-, R3 is Н, methoxy or -O-(CH2)n-O-, n=1-2, and also to the pharmaceutically acceptable salts thereof with acids which exhibit activity in relation to mycobacteria. The invention also relates to a method for producing compounds of formula (I), which consists in interacting corresponding arylquinolines with an aromatic ketone and using said compounds as an active principle in the creation of anti-tubercular medicinal preparations. |
申请公布号 |
WO2013039428(A2) |
申请公布日期 |
2013.03.21 |
申请号 |
WO2012RU00725 |
申请日期 |
2012.09.04 |
申请人 |
ZAKRYTOE AKTSIONERNOE OBSCHESTVO "PHARM-SINTEZ";NAZARENKO, ANNA BORISOVNA;FEDOROV, VLADIMIR EGOROVICH;ILIIN, VADIM EGOREVICH;OMELKOV, ANTON VLADIMIROVICH;RUCHKO, EVSEJ ALEKSANDROVICH |
发明人 |
NAZARENKO, ANNA BORISOVNA;FEDOROV, VLADIMIR EGOROVICH;ILIIN, VADIM EGOREVICH;OMELKOV, ANTON VLADIMIROVICH;RUCHKO, EVSEJ ALEKSANDROVICH |
分类号 |
C07D215/18 |
主分类号 |
C07D215/18 |
代理机构 |
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