发明名称 |
APTAMER FOR CHYMASE, AND USE THEREOF |
摘要 |
<p>Provided are an aptamer bound to chymase to inhibit activity of chymase; an aptamer containing a nucleotide sequence represented by X 1 GAUAGAN 1 N 2 UAAX 2 wherein X 1 and X 2 are the same or different and each is A or G, and N 1 and N 2 are the same or different and each is A, G, C, U or T; a complex containing the aptamer and a functional substance (e.g., affinity substance, labeling substance, enzyme, drug delivery medium, drug and the like); a pharmaceutical or a reagent containing the aptamer or complex; a detection and a purification methods of chymase using the aptamer or complex and the like.</p> |
申请公布号 |
EP2441833(A4) |
申请公布日期 |
2013.03.20 |
申请号 |
EP20100786245 |
申请日期 |
2010.06.11 |
申请人 |
RIBOMIC INC;OTSUKA PHARMACEUTICAL CO., LTD. |
发明人 |
NAKAMURA, YOSHIKAZU;JIN, LING;YAMAZAKI, SATOKO;IKEDA, HISAKO;MURAGUCHI, MASAHIRO |
分类号 |
C12N15/09;A61K31/7088;A61P9/00;A61P19/04;A61P43/00;C12Q1/68 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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