发明名称 |
METHOD OF DETECTING AND PROFILING PROGRESSION OF THE RISK OF NEURODEGENERATIVE DISEASES |
摘要 |
The present invention generally relates to methods of detecting and profiling progression of the risk of neurodegenerative diseases in a subject. In one embodiment, the method includes isolating a stem cell from cerebrospinal fluid of the subject and determining the level of H3K27 methylation within the stem cell. The subject is determined to have an increased risk of developing the neurodegenerative disease if the level of H3K27 methylation is elevated. In various embodiments, the neurodegenerative disease is Alzheimer's Disease, Parkinson's Disease or Amyotrophic Lateral Sclerosis.
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申请公布号 |
EP2569625(A1) |
申请公布日期 |
2013.03.20 |
申请号 |
EP20110780997 |
申请日期 |
2011.04.21 |
申请人 |
ANN AND ROBERT H. LURIE CHILDREN'S HOSPITAL OF CHICAGO |
发明人 |
MAYANIL, C., SHEKHAR;ICHI, SHUNSUKE;TOMITA, TADANORI |
分类号 |
G01N33/68 |
主分类号 |
G01N33/68 |
代理机构 |
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地址 |
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