发明名称 |
PROLONGED RELEASE MICROSPHERES FOR INJECTION DELIVERY AND PREPARATION METHOD |
摘要 |
The subject of the present invention is microspheres intended to be administered by injection, comprising a protein active ingredient and an agent coating the active ingredient intended to prolong its release, free of any trace of organic solvent and obtainable according to a coating method involving bringing the active ingredient and the coating agent into contact, with stirring, in a supercritical fluid, the said coating agent being soluble in the supercritical fluid. The protein active ingredient is not denatured. |
申请公布号 |
EP1303259(B1) |
申请公布日期 |
2013.03.20 |
申请号 |
EP20010938300 |
申请日期 |
2001.05.22 |
申请人 |
ETHYPHARM |
发明人 |
DULIEU, CLAIRE;RICHARD, JOEL;BENOIT, JEAN-PIERRE |
分类号 |
A61K9/16;A61K9/50;A61K9/58;A61K38/00;A61K38/04;A61K38/22;A61K38/27;A61K38/28;A61K38/43;A61K38/46;A61K38/55;A61K47/14;A61K47/24;A61K47/34;A61P7/00;A61P7/06;A61P35/00;A61P35/02 |
主分类号 |
A61K9/16 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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