Method for detecting aldehydes and ketones in glycerine

摘要

Quantitatively determining impurities in the form of aldehydes and ketones in glycerol processing for the production of drugs, comprises reacting the glycerol containing the impurities in a sample solution with a derivatizing reagent and determining the amount of derivatized impurities, where the derivatizing reagent is O-(2,3,4,5,6-pentafluorobenzyl)-hydroxylamine hydrochloride; the derivatization is carried out in the presence of a solubilizer in the form of a polar organic solvent; and a separation by liquid chromatography and a detection of the separated impurities are carried out.