| 发明名称 |
MODIFIED OLIGONUCLEOTIDES FOR TELOMERASE INHIBITION |
| 摘要 |
Compounds comprising an oligonucleotide moiety covalently linked to a lipid moiety are disclosed. The oligonucleotide moiety comprises a sequence that is complementary to the RNA component of human telomerase. The compounds inhibit telomerase activity in cells with a high potency and have superior cellular uptake characteristics.
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| 申请公布号 |
US2013065950(A1) |
申请公布日期 |
2013.03.14 |
| 申请号 |
US201213590511 |
申请日期 |
2012.08.21 |
| 申请人 |
GRYAZNOV SERGEI;PONGRACZ KRISZTINA;GERON CORPORATION |
发明人 |
GRYAZNOV SERGEI;PONGRACZ KRISZTINA |
| 分类号 |
C12N15/113;A61K31/7088;C12N5/071;C12N5/09;C12N9/99 |
主分类号 |
C12N15/113 |
| 代理机构 |
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