发明名称 |
BACTERIAL RNAS AS VACCINE ADJUVANTS |
摘要 |
The disclosure features vaccine adjuvants comprising prokaryotic mRNA, and methods of vaccination using the adjuvants. More specifically, the disclosure provides a vaccine composition comprising a nonviable immunogen (e.g., heat-killed bacterium), a tumor antigen, or an immunogenic peptide of microbial or mammalian origin, and an adjuvant, wherein adjuvant comprises prokaryotic mRNA (e.g., bacterial mRNA), as well as the methods of using the vaccine compositions. Further disclosed are the structual features of the prokaryotic mRNA used as the adjuvants. |
申请公布号 |
WO2013012875(A3) |
申请公布日期 |
2013.03.14 |
申请号 |
WO2012US47087 |
申请日期 |
2012.07.17 |
申请人 |
MOUNT SINAI SCHOOL OF MEDICINE;BLANDER, JULIE, MAGARIAN;SANDER, LEIF, ERIK |
发明人 |
BLANDER, JULIE, MAGARIAN;SANDER, LEIF, ERIK |
分类号 |
A61K48/00;A61K39/02 |
主分类号 |
A61K48/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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