CELECOXIB SOLID DISPERSION AND PREPARATION METHOD THEREFOR

摘要

A celecoxib solid dispersion, comprising celecoxib and a carrier material selected from polyvinylpyrrolidone, copovidone and crospovidone, wherein a ratio by weight of the carrier material to celecoxib is as low as 0.2:1. The solid dispersion is prepared by co-dissolving the carrier material and celecoxib into an organic solvent, or dispersing the carrier material into an organic solvent having celecoxib and then removing the organic solvent. The solid dispersion may be used to prepare a variety of solid formulations.