发明名称 |
METHODS FOR DETERMINING RESPONSIVENESS TO A DIHYDROFOLATE REDUCTASE INHIBITOR |
摘要 |
<p>The present disclosure provides methods for predicting or determining the sensitivity of a cell and/or biological sample obtained from a subject to a DHFR inhibitor including, for example, an antifolate such as Methotrexate or Pemetrexed. Such methods may comprise determining the expression level of one or more miRNAs (e.g., one or more members of the miR-181 and/or miR-143 families) in a cell or biological sample. The methods may be used to determine the responsiveness of a subject to treatment with a DHFR inhibitor.</p> |
申请公布号 |
WO2013036825(A1) |
申请公布日期 |
2013.03.14 |
申请号 |
WO2012US54248 |
申请日期 |
2012.09.07 |
申请人 |
TARGETED MOLECULAR DIAGNOSTICS, LLC;BACUS, SARAH;MORAN, DIARMUID |
发明人 |
BACUS, SARAH;MORAN, DIARMUID |
分类号 |
C12Q1/68;A61P35/00;C07H21/00;C40B30/06 |
主分类号 |
C12Q1/68 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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