GENETIC INHIBITION BY DOUBLE-STRANDED RNA

摘要

PROBLEM TO BE SOLVED: To provide a process for introducing an RNA into a living cell to inhibit gene expression of a target gene in that cell.

SOLUTION: The process may be practiced ex vivo or in vivo. The RNA has a region with double-stranded structure. Inhibition is sequence-specific in that the nucleotide sequences of the duplex region of the RNA and of a portion of the target gene are identical. The present invention is distinguished from prior art interference in gene expression by antisense or triple-strand methods.

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