发明名称 |
PHENOTYPIC REVERSION OF PANCREATIC CARCINOMA CELLS |
摘要 |
The present invention provides peptides (including analogs and derivatives thereof) corresponding to residues 96-110 and 35-47 of ras-p21, which peptides have attached thereto a membrane-penetrating leader sequence. The subject peptides, analogs and derivatives thereof are useful in treatment of cancers and have been shown to induce phenotypic reversion of pancreatic cancer cells to non-cancerous cells. Pharmaceutical compositions comprising one or more subject peptides are also provided by the present invention. The present invention further provides replication incompetent Adenovirus (AdV) vectors comprising a promoter sequence and a nucleotide sequence encoding a subject peptide. Methods of treating cancer by administering one or more subject peptides, pharmaceutical compositions, and/or AdV vectors are also provided. |
申请公布号 |
US2013065953(A1) |
申请公布日期 |
2013.03.14 |
申请号 |
US201213677876 |
申请日期 |
2012.11.15 |
申请人 |
PINCUS MATTHEW;MICHL JOSEF |
发明人 |
PINCUS MATTHEW;MICHL JOSEF |
分类号 |
A61K31/711;A61P35/00;C12N15/861 |
主分类号 |
A61K31/711 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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