MICRORNA-BASED METHODS AND ASSAYS FOR OSTEOSARCOMA

摘要

Provided are methods and compositions useful in the diagnosis, treatment, and monitoring of osteosarcoma. Antisense to certain microRNA (miRNA) found to be associated with cancer stem cells (CSCs) or tumor-initiating cells (TICs) of osteosarcoma are useful to suppress tumor growth and metastasis, and prolong survival. Antisense oligonucleotides to miR- 133a are synergistic in combination with standard chemotherapy such as cisplatin in the treatment of osteosarcoma.