发明名称 |
METHOD AND REAGENT FOR DIAGNOSIS AND/OR EVALUATION OF PROGRESSION OF GRAFT-VERSUS-HOST DISEASE |
摘要 |
Disclosed is a method of diagnosing graft-versus-host disease, comprising measuring the level of CCL8 protein in a sample obtained from a subject as an indicator for the diagnosis or course of graft-versus-host disease. Also a diagnostic reagent for graft-versus-host disease comprising an anti-CCL8 antibody is disclosed. The method of the present invention enables diagnosis of the onset of graft-versus-host disease and monitoring of the progress, in particular, differential diagnosis between graft-versus-host disease and an infectious disease. The present invention also provides a method for treating graft-versus-host disease utilizing the anti-CCL8 antibody. |
申请公布号 |
US2013065779(A1) |
申请公布日期 |
2013.03.14 |
申请号 |
US201213523791 |
申请日期 |
2012.06.14 |
申请人 |
HORI TSUKASA;KOKAI YASUO;NAISHIRO YASUYOSHI;TSUTSUMI HIROYUKI;IMAI KOHZOH;IMMUNO-BIOLOGICAL LABORATORIES CO., LTD. AND SAPPORO MEDICAL UNIVERSITY |
发明人 |
HORI TSUKASA;KOKAI YASUO;NAISHIRO YASUYOSHI;TSUTSUMI HIROYUKI;IMAI KOHZOH |
分类号 |
G01N33/566;C12Q1/37;C40B30/04;C40B40/10;G01N27/26;G01N27/62;G01N30/02 |
主分类号 |
G01N33/566 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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