A METHOD FOR MANUFACTURING PEGYLATED OLIGONUCLEOTIDES
摘要
A method for preparing a therapeutic pegylated oligonucleotide is described. The method involves synthesis, cleavage and purification steps designed to improve the efficiency whereby the therapeutic oligonucleotide may be prepared. Also described are methods for large scale preparation at the improved efficiency.
申请公布号
WO2012149198(A3)
申请公布日期
2013.03.14
申请号
WO2012US35270
申请日期
2012.04.26
申请人
REGADO BIOSCIENCES, INC.;BROOKS, DOUGLAS;RUSCONI, CHRISTOPHER, P.