The invention is directed to methods of measuring an immune response by comparing sequence-based clonotype frequency data from successively measured clonotype profiles. In particular, the invention includes immunotherapies of cancers, such as lymphomas, that include sensitive pre- and post-vaccination sequence-based measurements of changes in a patient's immune repertoire, thereby providing a sensitive measure of the likelihood of treatment success.
申请公布号
WO2013036459(A2)
申请公布日期
2013.03.14
申请号
WO2012US53530
申请日期
2012.08.31
申请人
SEQUENTA, INC.;FAHAM, MALEK;MOORHEAD, MARTIN;WILLIS, THOMAS