BICYCLO[6.1.0]NON-4-YNE REGENTS FOR CHEMICAL MODIFICATION OF OLIGONUCLEOTIDES

摘要

The present invention provides for compounds of Formulae I and II: wherein 1R, 2R, L, X, q, Z, A, and B have any of the values disclosed in the specification. Compounds of Formulae I and II are useful as reagents to introduce bicyclo[6.1.0]non-4-yne groups into oligonucleotide chains to serve as points of attachment for chemical tags.