METHOD FOR PREPARING DERIVATIVES OF KOJIC ACID

摘要

PURPOSE: A method for preparing a kojic acid derivative is provided to obtain a high purity kojic acid derivative by reacting halogenated kojic acid, which is the product of substituting a halogen element for a hydroxyl group of a hydroxyl methyl group, with benzoate or cinnamate. CONSTITUTION: A method for preparing a kojic acid derivative of chemical formula 1 comprises a step of reacting halogenated kojic acid with benzoate or cinnamate under the presence of acid. In chemical formula 1, R_1 is -CH_2- or -CH_2CH_2-; and R_2 is -C(O)OCH_2- or -CH=CHC(O)OCH_2-.