发明名称 |
METHODS AND TOOLS FOR SCREENING AGENTS EXHIBITING AN ACTIVITY ON RECEPTORS OF THE TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY |
摘要 |
<p>The present invention provides novel chimeric receptors and methods of screening using the chimeric receptors. The chimeric receptors comprise an extracellular domain of a type 1 single pass transmembrane receptor (T1SPTR) and an intracellular domain with kinase activity stemming from a receptor tyrosine kinase. According to an embodiment, the chimeric receptor comprises a full-length T1SPTR. According to another embodiment the chimeric receptor comprises a full-length or truncated tumor necrosis factor receptor (TNFR) or interleukin receptors, or cytokine receptors, or transforming growth factor receptors. The present invention provides means for screening of modulators of TNFRs or interleukin receptors, or cytokine receptors, or transforming growth factor receptors.</p> |
申请公布号 |
EP2566886(A1) |
申请公布日期 |
2013.03.13 |
申请号 |
EP20110718724 |
申请日期 |
2011.05.05 |
申请人 |
ADDEX PHARMA SA |
发明人 |
DE SMEDT, THIBAUT;GALIBERT, LAURENT;VAN DER VUURST DE VRIES, ANNE-RENEE;POUPARD, KEVIN |
分类号 |
C07K14/705;C07K14/71;C07K14/715;C12N15/62;G01N33/68 |
主分类号 |
C07K14/705 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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