发明名称 |
ANTAGONISTS OF SEMA3E/PLEXIND1 INTERACTION AS ANTI-CANCER AGENTS |
摘要 |
The present invention is related to the treatment of certain cancers using antagonists of the binding between a Plexin and a Sema3E. The invention may be helpful in treating primary cancer cell development and metastasis development wherein Sema3E is expressed, in particular overexpressed by the tumoral cells or the stroma. Breast cancer, in particular with distant metastases is concerned. Prostate cancer, melanoma and glioblastoma are also concerned. The antagonist may be any molecule that specifically binds to PlexinD1 or Sema3E and blocks the Sema3E/PlexinDl binding. In an embodiment, the antagonist is a polypeptide or an antibody. |
申请公布号 |
EP2566965(A2) |
申请公布日期 |
2013.03.13 |
申请号 |
EP20110717668 |
申请日期 |
2011.05.06 |
申请人 |
NETRIS PHARMA;CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (C.N.R.S.);UNIVERSITE DE LA MEDITERRANEE - AIX-MARSEILLE II |
发明人 |
ROYET, AMELIE;MANN, FANNY;CHAUVET, SOPHIE;LUCHINO, JONATHAN |
分类号 |
C12N15/113;A61K38/17;C07K14/705 |
主分类号 |
C12N15/113 |
代理机构 |
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地址 |
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