Pharmaceutical composition containing an N-phenylpyrazole derivative, use for the preparation of a topical veterinary drug for flea control

摘要

Liquid pharmaceutical composition (I) comprises: 5-amino-1-[2,6-dichloro-4-(trifluoromethyl)phenyl]-4-(trifluoromethylsulfinyl)-1H-pyrazole-3-carbonitrile (fipronil); benzyl alcohol (at least 5 wt./vol.%); and an organic solvent (at least 50 wt./vol/.%) comprising propylene glycol monomethyl ether, dipropylene glycol n-butyl ether, ethylene glycol monomethyl ether, ethylene glycol monoethyl ether, diethylene glycol monoethyl ether and/or propylene glycol, provided that (I) is free of alcohol 1-4C alcohol. ACTIVITY : Antiparasitic. MECHANISM OF ACTION : None given.