METHODS AND COMPOSITIONS FOR INHIBITION OF THE TRANSITIONAL ENDOPLASMIC RETICULUM ATPASE
摘要
<p>Compounds of Formulas I-XLIII are identified as direct inhibitors of p97 ATPase or of the degradation of a p97-dependent ubiquitin-proteasome system (UPS) substrate. Methods and compositions are disclosed for inhibiting p97 ATPase and the degradation of a p97-dependent UPS substrate, and for identifying inhibitors thereof.</p>
申请公布号
EP2566480(A2)
申请公布日期
2013.03.13
申请号
EP20110778469
申请日期
2011.05.06
申请人
CALIFORNIA INSTITUTE OF TECHNOLOGY;CLEAVE BIOSCIENCES, INC. (CLEAVE);THE UNIVERSITY OF KANSAS