发明名称 |
Phenylbutyryl curcumin derivatives and uses for preparing anti-tumor drugs thereof |
摘要 |
Provided are phenylbutyryl curcumin derivatives, their preparation methods, pharmaceutical compositions containing said derivatives and uses thereof for preparing anti-tumor drugs. Said curcumin derivatives are specifically 4-[bis(2-chloroethyl)amino]phenylbutyryl curcumin and 4,4'-bis[bis(2-chloroethyl)amino]phenylbutyryl curcumin, and their pharmaceutically acceptable salts. The curcumin derivatives are effective on inhibiting various animal tumor cell transplantation models in vivo, and do not have serious toxicity in mouse. |
申请公布号 |
GB2494595(A) |
申请公布日期 |
2013.03.13 |
申请号 |
GB20120023251 |
申请日期 |
2011.05.09 |
申请人 |
FUJIAN MEDICAL UNIVERSITY |
发明人 |
JIANHUA XU;YANG LIU;LIXAN WU;YANFANG LIN;ZHIJUIN WU;XIAODAN GUO;MIN WU |
分类号 |
C07C229/42;A61K31/216;A61P35/00;A61P35/02;C07C227/18 |
主分类号 |
C07C229/42 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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