发明名称 |
Tyrosine kinome |
摘要 |
Protein kinases are important signaling molecules involved in tumorigenesis. Mutational analysis of the human tyrosine kinase gene family (98 genes) identified somatic alterations in -20% of colorectal cancers, with the majority of mutations occurring in NTRK3, FES, GUCY2F and a previously uncharacterized tyrosine kinase gene called MCCK/MLK4. Most alterations were in conserved residues affecting key regions of the kinase domain. These data represent a paradigm for the unbiased analysis of signal transducing genes in cancer and provide useful targets for therapeutic intervention.
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申请公布号 |
US8394598(B2) |
申请公布日期 |
2013.03.12 |
申请号 |
US20100705760 |
申请日期 |
2010.02.15 |
申请人 |
BARDELLI ALBERTO;PARSONS WILL;VELCULESCU VICTOR;KINZLER KENNETH W.;VOGELSTEIN BERT;THE JOHNS HOPKINS UNIVERSITY |
发明人 |
BARDELLI ALBERTO;PARSONS WILL;VELCULESCU VICTOR;KINZLER KENNETH W.;VOGELSTEIN BERT |
分类号 |
C12Q1/68;A61B;C12N9/12;G01N33/574 |
主分类号 |
C12Q1/68 |
代理机构 |
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地址 |
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