Provided are recombinant mycobacteria having a mutation in an nlaA gene or in a nuoG gene. Also provided are isolated and purified nlaA proteins and nuoG proteins from a mycobacterium. Additionally provided are isolated and purified nucleic acids comprising a recombinant nlaA gene or a recombinant nuoG gene. Further provided are methods of inducing an immune response in a mammal and methods of making a recombinant mycobacterium using the nlaA gene or the nuoG gene.
申请公布号
US8394388(B2)
申请公布日期
2013.03.12
申请号
US20060794506
申请日期
2006.01.12
申请人
JACOBS, JR. WILLIAM R.;PORCELLI STEVEN A.;BRIKEN VOLKER;BRAUNSTEIN MIRIAM;ALBERT EINSTEIN COLLEGE OF MEDICINE OF YESHIVA UNIVERSITY
发明人
JACOBS, JR. WILLIAM R.;PORCELLI STEVEN A.;BRIKEN VOLKER;BRAUNSTEIN MIRIAM