发明名称 |
PIPERIDINESULFONYLUREAS AND -THIOUREAS, THEIR PREPARATION, THEIR USE AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM |
摘要 |
The present invention relates to piperidinesulfonylureas and piperidinesulfonylthioureas of the formula (I), in which A, X, R(1), R(2) and R(3) have the meanings indicated in the claims. The compounds of the formula (I) are valuable active pharmaceutical ingredients which show in particular an inhibiting effect on ATP-sensitive potassium channels of the cardiac muscle and are suitable, for example, for the treatment of disorders of the cardiovascular system such as coronary heart disease, arrhythmias, cardiac insufficiency, cardiomyopathies or reduced contractility of the heart or for the prevention of sudden cardiac death. The invention further relates to processes for preparing the compounds of the formula (I), their use and pharmaceutical compositions comprising them.
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申请公布号 |
CA2590405(C) |
申请公布日期 |
2013.03.12 |
申请号 |
CA20052590405 |
申请日期 |
2005.12.07 |
申请人 |
SANOFI-AVENTIS DEUTSCHLAND GMBH |
发明人 |
KNIEPS, STEPHANIE;ENGLERT, HEINRICH CHRISTIAN;GERLACH, UWE;GOEGELEIN, HEINZ;HEITSCH, HOLGER;LEHR, KARL-HEINZ;PFEIFFER-MAREK, STEFANIA |
分类号 |
C07D211/96;A61K31/445 |
主分类号 |
C07D211/96 |
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