发明名称 7-aza-spiro[3.5]nonane-7-carboxylate derivatives, preparation thereof and therapeutic use thereof
摘要 The invention relates to compounds of the general formula (I) where: R2 is a hydrogen or fluorine atom or a hydroxyl, cyano, trifluoromethyl, C1-6-alkyl, C1-6-alkoxy, or NR8R9 group; m, n, o and p independently are a number from 0 to 3, provided that m+n≰7 and that o+p≰7; A is a covalent bond, an oxygen atom, a C1-6-alkylene group or a—O—C1-6-alkylene group in which the end that is an oxygen atom is bonded to the R1 group and the end that is an alkylene group is bonded to the carbon of the bicyclic compound; R1 is an optionally substituted aryl or heteroaryl group; R3 is a hydrogen or fluorine atom or a C1-6-alkyl or trifluoromethyl group; R4 is an optionally substituted 5-membered heterocyclic compounds; wherein the compounds can be in the state of a base or an acid addition salt. The invention can be used in therapeutics.
申请公布号 US8394787(B2) 申请公布日期 2013.03.12
申请号 US201013320199 申请日期 2010.05.11
申请人 ABOUABDELLAH AHMED;CHEREZE NATHALIE;FAYOL AUDE;LOCHEAD ALISTAIR;SAADY MOURAD;VACHE JULIEN;YAICHE PHILIPPE;SANOFI 发明人 ABOUABDELLAH AHMED;CHEREZE NATHALIE;FAYOL AUDE;LOCHEAD ALISTAIR;SAADY MOURAD;VACHE JULIEN;YAICHE PHILIPPE
分类号 A61K31/397;A61K31/421;A61K31/422;A61K31/438;C07D205/12;C07D221/20;C07D261/06;C07D263/30 主分类号 A61K31/397
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