| 摘要 |
1,265,446. 7 - Nitro - estratrienes. SOC. FARMACEUTICI ITALIA. 8 June, 1970 [11 June, 1969], No. 27544/70. Heading C2U. Novel steroids of the formula wherein R is H, C 1-4 alkyl, omega-halo-C 1-2 alkyl, C 5-6 cycloaliphatic, C 1-4 aliphatic acyl or C 5-8 cycloaliphatic acyl; R<SP>1</SP> is H, C 1-4 aliphatic acyi or C 5-8 cycloaliphatic acyl; R<SP>11</SP> is H , ethynyl or 1-butynyl, or OR<SP>1</SP>+R<SP>11</SP> is oxo; and R<SP>1</SP> is H(#-OH), H(#-ONO 2 ) or = O; are prepared by reacting corresponding 6,7 - unsubstituted- 6,7-dehydro-steroids with a nitrating agent such as fuming nitric acid or nitrogen dioxide at from - 20‹ to +5‹ C. under anhydrous conditions. The required 7α-nitro-steroids may be isolated from the reaction solution, after neutralization, by extraction with an organic solvent, and separated by chromatography. 3 - Methoxy . 1,3,5(10),6 - estratetraen - 17# - ol acetate is prepared from the 3-ol and diazomethane; The novel steroids have estrogenic activity, and they may be made up into pharmaceutical compositions with suitable carriers. |
