| 发明名称 |
USE OF HETEROCYCLIC CARBALDEHYDE DERIVATIVES AGAINST SICKLE CELL ANEMIA |
| 摘要 |
<p>The invention provides compounds for the treatment of sickle-cell disease. In particular, the invention provides 5-membered heterocyclic anti-sickling agents that are highly effective and nontoxic, and methods for their use. The compounds include analogues and derivatives of naturally occurring 5-hydroxymethyl-2-furfuraldehyde, 5-Ethyl-2-furfuraldehyde, 5-Methyl-2furfuraldehyde, and 2-furfuraldehyde, and prodrug forms of the compound.</p> |
| 申请公布号 |
PT2179987(E) |
申请公布日期 |
2013.03.11 |
| 申请号 |
PT20100152353T |
申请日期 |
2003.12.03 |
| 申请人 |
VIRGINIA COMMONWEALTH UNIVERSITY |
发明人 |
MARTIN K. SAFO;RICHMOND DANSO-DANQUAH;SAMUEL NOKURI;FAIK N. MUSAYEV;GAJANAN S. JOSHI;JAMES C. BURNETT;DONALD J. ABRAHAM |
| 分类号 |
C07D307/48;A61K31/34;A61K31/341;A61K31/381;A61K31/40;A61K31/401;A61K31/66;A61P7/00;C07D207/30;C07D417/04 |
主分类号 |
C07D307/48 |
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