DRUG PREPARATION WITH ANTIARRHYTHMIC AND ANTIFIBRILLATORY ACTION

摘要

FIELD: medicine, pharmaceutics.SUBSTANCE: what is presented is using amide N-succinyl-L-glutamide-L-lysine (GC-1) representing a dipeptide agonist of nerve growth factor as an antiarrhythmic and antifibrillatory agent for preventing sudden cardiac death. It is shown that the agonist of nerve growth factor - the GC-1 compound (1 mg/kg intravenously) on a model of electrical ventricular fibrillation possess antiarrhythmic (antifibrillatory) action being as good as reference antiarrhythmic drug preparations of Vaughan Williams class I and III.EFFECT: obtained data give ground for presenting using the GC-1 dipeptide as an antiarrhythmic (antifibrillatory) drug preparation which may be used in clinical practise for preventing sudden coronary death.1 dwg, 2 tbl, 3 ex