| 摘要 |
FIELD: chemistry.SUBSTANCE: invention relates to chemical industry and chemical functionalisation of fullerene C, particularly a method for synthesis of organic derivatives of [70] fullerene, including those soluble in water and physiological media. More specifically, the invention relates to novel water-soluble derivatives of fullerene Cof general formula, where in general formula 1, X denotes a methylene group (CH), oxygen (O), sulphur (S), nitrogen (NH or NR, where R is an aliphatic acid residue -(CH)COOH, where m ranges from 1 to 99); the number of methylene links n in the chain which binds the solubilising COOH group and a CHX fragment ranges from 0 to 99; as well as to a method of producing water-soluble arylated Cfullerene derivatives of general formula 1 upon reaction of chlorofullerenes with aromatic acid esters followed by hydrolysis, where the chlorofullerenes used are CCand/or CClchlorofullerenes.EFFECT: invention can be used in biomedical research and in production of novel medical drugs for therapy in human and animal diseases.2 cl, 3 ex, 5 dwg |
